The Origin of Disease | Anna L. Caputo

v1.0 · January 2026 · See how the framework has evolved

GLP-1s help Parkinson's, Alzheimer's, heart disease, addiction, and a dozen other "unrelated" conditions. No one understands why.

The answer is sitting in the research, scattered across cardiology, oncology, neurology, psychiatry, immunology. Each specialty has documented their piece, but no one has stepped back to see the whole picture.

This book does.

Medicine's own data. Finally connected.

Dedication

To anyone who's ever been handed a lifelong diagnosis

We finally made it to the other side of history.

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Contents

I. What Medicine Missed
When Medicine Stopped Asking Questions 1
Seventy Years of Data 2
II. What the Data Reveals
The Call Was Coming From Inside the House 3
The State of Disease 4
What Makes a Good Theory 5
Overloaded 6
III. The Bridge
False Paradox 7
The Dark Side of Diagnosis 8
IV. Why We're Stuck
The "Fixed" Brain 9
The Driver 10
V. What We Can Do Now
How We Learn 11
If Evolution Isn't Going to Fix It... 12
Mechanism for Change 13
All Roads Lead to Rome 14